Liang Zhi-bin, Chen Yu-mei, Chen Yu-fan, Cheng Ying-ying, Zhang Lian-hui
Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
Yi Chuan. 2016 Oct 20;38(10):894-901. doi: 10.16288/j.yczz.16-139.
Antibiotic resistance has become a serious concern in treatment of bacterial infections. Overexpression of efflux pump is one of the important mechanisms in antibiotic resistance. In Gram negative bacteria, RND (Resistance-nodulation-cell division) superfamily efflux pump plays a vital important role in antibiotics resistance. Recent research progress unveils an intriguing interrelationship between RND efflux pump and the bacterial quorum sensing system, whose regulation is dependent on small signal molecules. This article reviews the latest findings on the structure and transport mechanism of RND efflux pump, as well as the general features and regulatory mechanisms of quorum sensing, with a special focus on the role and mechanism of quorum sensing system in regulation of RND efflux pump, and the influence of efflux pump on quorum sensing signal transportation. Further investigation of the interrelationship between RND efflux pumps and the bacterial quorum sensing systems is critical for elucidation of the regulatory mechanisms that govern the expression of the RND efflux pumps genes, and may also provide useful clues to overcome the efflux pump mediated antibiotic resistance.
抗生素耐药性已成为细菌感染治疗中的一个严重问题。外排泵的过度表达是抗生素耐药性的重要机制之一。在革兰氏阴性菌中，RND（耐药-结瘤-细胞分裂）超家族外排泵在抗生素耐药性中起着至关重要的作用。最近的研究进展揭示了RND外排泵与细菌群体感应系统之间一种有趣的相互关系，其调节依赖于小信号分子。本文综述了RND外排泵的结构和转运机制的最新研究成果，以及群体感应的一般特征和调节机制，特别关注群体感应系统在调节RND外排泵中的作用和机制，以及外排泵对群体感应信号传递的影响。进一步研究RND外排泵与细菌群体感应系统之间的相互关系，对于阐明调控RND外排泵基因表达的调节机制至关重要，也可能为克服外排泵介导的抗生素耐药性提供有用线索。
