Wozniak K M, Aulakh C S, Hill J L, Murphy D L
Laboratory of Clinical Science National Institute of Mental Health, Bethesda, MD 20892.
Pharmacol Biochem Behav. 1989 May;33(1):265-7. doi: 10.1016/0091-3057(89)90461-9.
Intravenous administration of m-chlorophenylpiperazine (m-CPP, a serotonin agonist) to rats increased plasma prolactin and corticosterone concentrations. Long-term (21-day) and short-term (3-day) treatment with the tricyclic antidepressant, clomipramine, did not have any significant effect on baseline levels of either prolactin or corticosterone. Long-term but not short-term clomipramine treatment significantly potentiated m-CPP's effect on plasma prolactin. On the other hand, both long-term and short-term clomipramine treatment significantly attenuated m-CPP's effect on plasma corticosterone. These findings are consistent with other animal and clinical studies demonstrating a differential effect of antidepressant treatment on two different serotonin-mediated neuroendocrine functions.
给大鼠静脉注射间氯苯哌嗪（m-CPP，一种血清素激动剂）会增加血浆催乳素和皮质酮浓度。用三环类抗抑郁药氯米帕明进行长期（21天）和短期（3天）治疗，对催乳素或皮质酮的基线水平均无显著影响。长期而非短期的氯米帕明治疗显著增强了m-CPP对血浆催乳素的作用。另一方面，长期和短期的氯米帕明治疗均显著减弱了m-CPP对血浆皮质酮的作用。这些发现与其他动物和临床研究一致，表明抗抑郁治疗对两种不同的血清素介导的神经内分泌功能有不同影响。
