King W, Ellison G
Department of Psychology, University of Wisconsin, Platteville.
Pharmacol Biochem Behav. 1989 May;33(1):69-73. doi: 10.1016/0091-3057(89)90431-0.
Groups of rats were administered either 80 micrograms LSD-25 continuously over seven days using subcutaneous minipumps, or were given the same total amount of drug in seven daily injections, or were administered vehicle. When tested long after cessation of drug administration, persisting alterations in behavior and brain were found in the continuous LSD groups. In social open-field tests, this consisted of decreased social distance between animals; this effect increased upon repeated testing. In uptake of labeled ligands, this was reflected predominantly by decreased 3H-LSD binding in several limbic regions. LSD appears to have especially persisting neurotoxic effects when administered in a continuous, low-level fashion.
将大鼠分组，一组使用皮下微型泵在七天内连续给予80微克麦角酸二乙酰胺（LSD - 25），另一组在七天内每日注射相同总量的药物，还有一组给予赋形剂。在停止给药很长时间后进行测试时，发现连续给予LSD的组中行为和大脑存在持续改变。在社交旷场试验中，表现为动物之间社交距离缩短；重复测试时这种效应增强。在标记配体摄取方面，主要表现为几个边缘区域中3H - LSD结合减少。当以连续、低剂量方式给药时，LSD似乎具有特别持久的神经毒性作用。
