Steenbergen H L, Heinsbroek R P, Van Haaren F, Van de Poll N E
Netherlands Institute for Brain Research, Amsterdam.
Physiol Behav. 1989 Apr;45(4):781-7. doi: 10.1016/0031-9384(89)90295-3.
Stress-induced behavioral disturbances have widely been used as animal models of depression. Sex differences, however, have rarely been studied, even though evidence is available to show that males and females react differently after presentation of aversive stimuli. The present experiment investigated the behavioral effects of inescapable shocks on subsequent shuttlebox-escape performance in male and female rats. Exposure to inescapable shocks resulted in suppression of activity during shock administration, which was more severe when shock duration was increased. Females showed less behavioral suppression and they were also more active than males during the adaptation phase, prior to shuttlebox-escape training. Shuttlebox-escape performance was less affected in females than in males compared to that of nonshocked control subjects. Shock duration as a factor only affected efficiency of shuttlebox-escape performance in males.
应激诱导的行为障碍已被广泛用作抑郁症的动物模型。然而，尽管有证据表明雄性和雌性在受到厌恶刺激后的反应不同，但性别差异却很少被研究。本实验研究了不可逃避电击对雄性和雌性大鼠随后穿梭箱逃避性能的行为影响。暴露于不可逃避的电击会导致电击期间活动受到抑制，当电击持续时间增加时，这种抑制会更严重。在穿梭箱逃避训练之前的适应阶段，雌性表现出较少的行为抑制，并且比雄性更活跃。与未受电击的对照动物相比，雌性的穿梭箱逃避性能受影响小于雄性。电击持续时间作为一个因素仅影响雄性穿梭箱逃避性能的效率。
