O'Byrne K T, Lunn S F, Dixson A F
M.R.C. Reproductive Biology Unit, Edinburgh.
Physiol Behav. 1989 May;45(5):1077-80. doi: 10.1016/0031-9384(89)90241-2.
There is considerable evidence suggesting that endogenous opioid peptides (EOP) might play a role in the defensive response to stressful stimuli. The stress associated with receipt of aggression from a female conspecific and physical restraint for collection of serial blood samples (at 10-min intervals) resulted in a significant (p less than 0.05) suppression of LH secretion in the oestradiol primed ovariectomized marmoset. Administration of the opioid receptor antagonist, Naloxone (1 mg/kg) immediately before and after receipt of aggression completely prevented the stress-induced decrease in LH release. This suggests that EOP may mediate, at least in part, this stress induced decline in LH release in the marmoset.
有大量证据表明内源性阿片肽（EOP）可能在对应激刺激的防御反应中发挥作用。与来自雌性同种动物的攻击以及为采集系列血样（每隔10分钟采集一次）而进行的身体束缚相关的应激，导致在经雌二醇预处理的去卵巢狨猴中促黄体生成素（LH）分泌显著受到抑制（p小于0.05）。在遭受攻击之前和之后立即给予阿片受体拮抗剂纳洛酮（1毫克/千克），完全阻止了应激诱导的LH释放减少。这表明EOP可能至少部分介导了狨猴中这种应激诱导的LH释放下降。
