Bastianelli Carlo, Farris Manuela, Bruno Vecchio Roberta Costanza, Rosato Elena, Guida Maurizio, Benagiano Giuseppe
a Department of Gynecological and Obstetrical Sciences and Urological Sciences , Sapienza University of Rome , Rome , Italy.
b Italian Association for Demographic Education, AIED , Rome , Italy , and.
Gynecol Endocrinol. 2017 Feb;33(2):168-172. doi: 10.1080/09513590.2016.1240776. Epub 2016 Nov 4.
To analyze adherence to an oral contraceptive (OC) regimen and correlate results to participants' socio-demographic and behavioral characteristics.
Women were prospectively enrolled and followed for 6 months. At enrollment, subjects were given a card for recording daily pill intake; its completion was checked at 6 months when women completed a self-administered questionnaire.
Out of 755 eligible subjects, 704 agreed to participate; 402 women completed 6 months of recording of use of an OC and properly filled the questionnaire. Good adherence was reported by 64% of participants; 20.9% missed one pill and 14.9% missed more than one pill. Mean number of missed pills per subject was 0.59 and mean number of pills delayed for less than 24 h was 1.18. Best adherence to a COC regimen was associated with evening time intake (p = 0.0019). No statistically significant associations of adherence with socio-demographic characteristics were found. Age was only marginally associated with having missed at least one pill.
In the present study, a lower number of missed pills were observed than previously reported, but the proportion of missed pills was similar. No association with specific subject characteristics that could serve as markers of increased risk of nonadherence was found.
分析口服避孕药（OC）方案的依从性，并将结果与参与者的社会人口学和行为特征相关联。
前瞻性招募女性并随访6个月。在入组时，为受试者发放一张记录每日服药情况的卡片；在6个月时女性完成一份自填式问卷时检查卡片填写情况。
在755名符合条件的受试者中，704人同意参与；402名女性完成了6个月的口服避孕药使用记录并正确填写了问卷。64%的参与者报告依从性良好；20.9%的人漏服了一片药，14.9%的人漏服不止一片药。每位受试者漏服药片的平均数量为0.59片，延迟服用少于24小时的药片平均数量为1.18片。复方口服避孕药（COC）方案的最佳依从性与晚间服药有关（p = 0.0019）。未发现依从性与社会人口学特征之间存在统计学上的显著关联。年龄与至少漏服一片药仅存在微弱关联。
在本研究中，观察到漏服药片的数量低于先前报告，但漏服药片的比例相似。未发现与可作为不依从风险增加标志的特定受试者特征存在关联。
