Valdés Karina, Morales Javier, Rodríguez Lennin, Günther Germán
Departamento de Ciencias y Tecnología Farmacéutica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo, Perú.
Nanomedicine (Lond). 2016 Dec;11(23):3139-3156. doi: 10.2217/nnm-2016-0251. Epub 2016 Nov 4.
Ursolic, oleanolic and betulinic acids are representative pentacyclic triterpenoids found in various plants and fruits. Despite having marked antitumor potentials, the very poor water solubility of these triterpenes hinders treatment development. Nanotechnology can enhance solubility, stability, bioavailability and phytochemical delivery, improving the therapeutic efficiency of triterpenes. This review focuses on the formulation, characterization and in vitro/in vivo evaluation of several delivery nanosystems used to enhance the physicochemical properties of ursolic, oleanolic and betulinic acids.
熊果酸、齐墩果酸和桦木酸是在各种植物和水果中发现的代表性五环三萜类化合物。尽管这些三萜类化合物具有显著的抗肿瘤潜力，但其极差的水溶性阻碍了治疗开发。纳米技术可以提高溶解度、稳定性、生物利用度和植物化学物质的递送，从而提高三萜类化合物的治疗效率。本文综述了几种用于增强熊果酸、齐墩果酸和桦木酸物理化学性质的递送纳米系统的制剂、表征及体外/体内评价。
