植物化学物质治疗阿尔茨海默病：系统评价。
Phytochemicals in the Treatment of Alzheimer's Disease: A Systematic Review.
机构信息
Geriatric Unit & Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
Shanghai Institute of Geriatrics and Gerontology, Shanghai Key Laboratory of Clinical Geriatrics, Department of Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Shanghai Medical College, Fudan University, Shanghai 200040, China.
出版信息
Curr Drug Targets. 2017;18(13):1487-1498. doi: 10.2174/1389450117666161102121553.
BACKGROUND
Alzheimer's disease (AD) is the most widespread age-related neurodegenerative disease. Recently, a growing body of evidence suggested the phytochemical use to slow down AD onset and progression.
OBJECTIVE
To review the phytochemical role potentially involved in AD treatment.
METHOD
A systematic review from existing literature on phytochemicals used in the treatment of AD patients was conducted. Selection criteria included: 1) age≥60 years; 2) AD diagnosis in agreement with the criteria of National Institute on Aging-Alzheimer's Association (NIAAA), and 3) suitable measures to asses cognitive, functional and clinical status.
RESULTS
Ninety-seven articles were involved in the present study. Several phytochemicals seem to slow down AD onset, delay disease progression and let recovery through targeting multiple pathological causes by anti-cholinergic, antioxidant and anti-inflammatory features.
CONCLUSION
Deeper knowledge on phytochemicals and their specific molecular targets is essential to guarantee safe use of these compounds as an option for AD treatment.
背景
阿尔茨海默病（AD）是最常见的与年龄相关的神经退行性疾病。最近，越来越多的证据表明植物化学物质的使用可以减缓 AD 的发病和进展。
目的
综述植物化学物质在 AD 治疗中可能发挥的作用。
方法
对用于治疗 AD 患者的植物化学物质的现有文献进行了系统综述。选择标准包括：1）年龄≥60 岁；2）AD 诊断符合美国国家老龄化研究所-阿尔茨海默病协会（NIAAA）的标准，以及 3）有合适的措施来评估认知、功能和临床状况。
结果
本研究共涉及 97 篇文章。一些植物化学物质似乎可以通过抗胆碱能、抗氧化和抗炎作用，针对多种病理原因，减缓 AD 的发病，延缓疾病的进展，并促进恢复。
结论
更深入地了解植物化学物质及其特定的分子靶点对于保证这些化合物的安全使用是至关重要的，因为这些化合物可以作为 AD 治疗的一种选择。
Zotero 插件