Belkhelladi Malachy
Biochemistry, McGill University, Montreal, CAN.
Cureus. 2023 Dec 28;15(12):e51225. doi: 10.7759/cureus.51225. eCollection 2023 Dec.
This systematic review evaluates the effects of the daily intake of rosehip extract on low-density lipoprotein cholesterol (LDL-C) and blood glucose levels. It synthesizes findings from randomized clinical trials focusing on cardiovascular and metabolic health outcomes. The review includes studies employing various forms of rosehip supplementation, assessing primary outcomes such as LDL-C, HDL-C, total cholesterol, triglycerides, fasting blood glucose (FBG), and glycated hemoglobin (HbA1c). Secondary outcomes, such as body weight, BMI, and blood pressure, are also considered. The paper discusses the potential mechanisms of rosehip's action, including modulation of peroxisome proliferator-activated receptors and effects on various metabolic pathways. The results indicate mixed effects on lipid profiles and blood glucose levels, with some studies showing significant benefits. This review underscores the need for further research to confirm optimal dosages, treatment durations, and rosehip's efficacy in diverse populations, considering its favorable safety profile. The findings suggest the potential of rosehip extract as a complementary agent in managing cardiometabolic risk factors.
本系统评价评估了每日摄入玫瑰果提取物对低密度脂蛋白胆固醇（LDL-C）和血糖水平的影响。它综合了聚焦于心血管和代谢健康结局的随机临床试验的结果。该评价纳入了采用各种形式玫瑰果补充剂的研究，评估的主要结局包括LDL-C、高密度脂蛋白胆固醇（HDL-C）、总胆固醇、甘油三酯、空腹血糖（FBG）和糖化血红蛋白（HbA1c）。还考虑了次要结局，如体重、体重指数（BMI）和血压。本文讨论了玫瑰果作用的潜在机制，包括过氧化物酶体增殖物激活受体的调节以及对各种代谢途径的影响。结果表明对血脂谱和血糖水平有混合效应，一些研究显示出显著益处。考虑到玫瑰果良好的安全性，本评价强调需要进一步研究以确定最佳剂量、治疗持续时间以及玫瑰果在不同人群中的疗效。研究结果表明玫瑰果提取物作为管理心血管代谢危险因素的辅助剂具有潜力。
