Zheng Yuzhou, Wang Tangrong, Zhang Jiaxin, Wei Sen, Wu Zhijing, Li Jiali, Shi Beihao, Sun Zixuan, Xu Wenrong, Zhu Jian
Vascular Surgery Department, Affiliated Kunshan Hospital of Jiangsu University, Kunshan 215300, China.
Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
J Agric Food Chem. 2025 Jun 4;73(22):13159-13177. doi: 10.1021/acs.jafc.5c01547. Epub 2025 May 22.
In recent years, mammal-derived extracellular vesicles (EVs) have been widely used in studies on tissue repair and antiaging. Their therapeutic potential lies in mediating intercellular communication through the transfer of various bioactive molecules. As research on nanovesicles progresses, plant-derived nanovesicles (PDNVs) have attracted growing attention as a promising alternative. As an emerging cross-species regulatory "natural force", PDNVs have attracted considerable interest due to their excellent biocompatibility, low immunogenicity, and remarkable therapeutic effects in tissue injury and aging-related diseases. In this review, we examine the bioactive components, drug delivery potential, and functional mechanisms of PDNVs, and we summarize recent advances in their applications for tissue repair and antiaging. In addition, we systematically discuss the major challenges and limitations hindering the clinical translation and industrialization of PDNVs, and we propose five strategic approaches along with future research directions. This review aims to promote further investigation of PDNVs in regenerative medicine and enhance their potential for clinical application.
近年来，哺乳动物来源的细胞外囊泡（EVs）已广泛应用于组织修复和抗衰老研究。它们的治疗潜力在于通过各种生物活性分子的传递来介导细胞间通讯。随着对纳米囊泡研究的进展，植物来源的纳米囊泡（PDNVs）作为一种有前景的替代物受到越来越多的关注。作为一种新兴的跨物种调节“自然力量”，PDNVs因其出色的生物相容性、低免疫原性以及在组织损伤和衰老相关疾病中的显著治疗效果而备受关注。在本综述中，我们研究了PDNVs的生物活性成分、药物递送潜力和功能机制，并总结了它们在组织修复和抗衰老应用方面的最新进展。此外，我们系统地讨论了阻碍PDNVs临床转化和产业化的主要挑战和限制，并提出了五种战略方法以及未来的研究方向。本综述旨在促进对PDNVs在再生医学中的进一步研究，并提高其临床应用潜力。
