Long Erping, Chen Jingjing, Liu Zhenzhen, Lin Zhuoling, Cao Qianzhong, Zhang Xiayin, Li Xiaoyan, Luo Lixia, Lin Haotian, Chen Weirong, Liu Yizhi
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
BMC Ophthalmol. 2016 Nov 3;16(1):192. doi: 10.1186/s12886-016-0371-5.
Congenital cataracts are often complicated by anterior segment dysgenesis. This study aims to compare bilateral anterior segment parameters, macular thickness, and best-corrected visual acuity (BCVA) in pediatric cataract patients at 3 months after unilateral cataract extraction with intraocular lens implantation.
Fifty-three pediatric patients with uncomplicated unilateral total cataracts were included. At 3 months post-surgery, bilateral corneal thickness at the thinnest location (CTTL), anterior chamber depth (ACD), and anterior chamber volume (ACV) were measured using Pentacam. Central macular thickness (CMT) was evaluated using spectral-domain optical coherence tomography. BCVA was measured by experienced optometrists concurrently. Descriptive statistics and bivariate corrections were performed to analyze the interocular differences in bilateral anatomic parameters and their relationships with BCVA.
For all 53 included patients (mean age 5.2 ± 2.3 years), the median BCVA was 10/40 in the operated eyes and 40/40 in the contralateral eyes, which indicates a significant interocular difference. BCVA values in the contralateral eyes were significantly correlated with patient age at surgery, but this result differed for BCVA in the operated eyes. The Pentacam analysis revealed no significant interocular differences in bilateral CTTL and ACV, but significant differences were found for ACD.
At 3 months after surgery, unilateral pediatric cataract patients exhibited no significant interocular differences in identified anatomical parameters (except for ACD), and these parameters were not significantly correlated with BCVA in bilateral eyes. Therefore, amblyopia, but not anatomical factors, might be the main cause of interocular visual functional differences in our study population.
ClinicalTrial.gov, NCT02765230 , 05/05/2016, retrospectively registered.
先天性白内障常合并前段发育异常。本研究旨在比较小儿白内障患者单侧白内障摘除联合人工晶状体植入术后3个月时的双眼前段参数、黄斑厚度和最佳矫正视力（BCVA）。
纳入53例患有单纯性单侧完全性白内障的小儿患者。术后3个月，使用Pentacam测量双眼最薄处的角膜厚度（CTTL）、前房深度（ACD）和前房容积（ACV）。使用频域光学相干断层扫描评估中央黄斑厚度（CMT）。由经验丰富的验光师同时测量BCVA。进行描述性统计和双变量校正，以分析双眼解剖参数的眼间差异及其与BCVA的关系。
对于所有纳入的53例患者（平均年龄5.2±2.3岁），手术眼的BCVA中位数为10/40，对侧眼为40/40，表明存在显著的眼间差异。对侧眼的BCVA值与手术时的患者年龄显著相关，但手术眼的BCVA结果则不同。Pentacam分析显示，双眼CTTL和ACV无显著眼间差异，但ACD存在显著差异。
术后3个月，单侧小儿白内障患者在已确定的解剖参数（ACD除外）上无显著眼间差异，且这些参数与双眼BCVA无显著相关性。因此，在我们的研究人群中，弱视而非解剖因素可能是眼间视觉功能差异的主要原因。
ClinicalTrial.gov，NCT02765230，2016年5月5日，回顾性注册。
