SaOS-2细胞对铸造Mg-2.0Zn0.98Mn镁合金腐蚀行为的影响
Influence of SaOS-2 cells on corrosion behavior of cast Mg-2.0Zn0.98Mn magnesium alloy.
作者信息
Witecka Agnieszka, Yamamoto Akiko, Święszkowski Wojciech
机构信息
International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, Japan; Faculty of Materials Science and Engineering, Warsaw University of Technology (WUT), 141 Woloska Street, Warsaw 02-507, Poland.
International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0044, Japan.
出版信息
Colloids Surf B Biointerfaces. 2017 Feb 1;150:288-296. doi: 10.1016/j.colsurfb.2016.10.041. Epub 2016 Oct 25.
In this research, the effect of the presence of living cells (SaOS-2) on in vitro degradation of Mg-2.0Zn-0.98Mn (ZM21) magnesium alloy was examined by two methods simple immersion/cell culture tests and electrochemical measurements (electrochemical impedance spectroscopy and potentiodynamic polarization) under cell culture conditions. In immersion/cell culture tests, when SaOS-2 cells were cultured on ZM21 samples, pH of cell culture medium decreased, therefore weight loss and Mg ion release from the samples increased. Electrochemical measurements revealed the presence of living cells increased corrosion rate (I) and decreased polarization resistance (R) after 48h of incubation. This acceleration of ZM21 corrosion can mainly be attributed to the decrease of medium pH due to cellular metabolic activities.
在本研究中，通过两种方法，即简单浸泡/细胞培养试验以及在细胞培养条件下的电化学测量（电化学阻抗谱和动电位极化），研究了活细胞（SaOS-2）的存在对Mg-2.0Zn-0.98Mn（ZM21）镁合金体外降解的影响。在浸泡/细胞培养试验中，当在ZM21样品上培养SaOS-2细胞时，细胞培养基的pH值降低，因此样品的重量损失和镁离子释放增加。电化学测量表明，培养48小时后，活细胞的存在增加了腐蚀速率（I）并降低了极化电阻（R）。ZM21腐蚀的这种加速主要可归因于细胞代谢活动导致培养基pH值的降低。
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