成年海马神经发生：从干细胞到行为。

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior.

机构信息

Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

出版信息

Cell. 2016 Nov 3;167(4):897-914. doi: 10.1016/j.cell.2016.10.021.

DOI:10.1016/j.cell.2016.10.021

Abstract

The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the molecular machinery involved in the generation of new neurons from a pool of adult neural stem cells and their integration into functional hippocampal circuits. We also summarize the potential functions of these newborn neurons in the adult brain, their contribution to behavior, and their relevance to disease.

摘要

哺乳动物海马回的齿状回在成年期持续产生新的神经元。这些成年新生神经元变得具有功能活性，被认为有助于学习和记忆，尤其是在它们的成熟阶段，此时它们具有非凡的可塑性。在这篇综述中，我们讨论了从成体神经干细胞池中产生新神经元的分子机制及其整合到功能性海马回回路中的过程。我们还总结了这些新生神经元在成年大脑中的潜在功能、它们对行为的贡献以及它们与疾病的相关性。