一种来自乌药的新酚苷。
A new phenolic glycoside from Lindera nacusua.
作者信息
Lei Jie-Ping, Wei Guo-Qing, Yuan Juan-Juan, Tan Kang-Zhi, Chen Qiao-Yu, Zhang Tao, Ma Chao-Ying, Jiang He-Zhong
机构信息
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , P.R. China.
b Department of Oncology , Chengdu Military General Hospital , Chengdu , P.R. China.
出版信息
Nat Prod Res. 2017 Apr;31(8):896-901. doi: 10.1080/14786419.2016.1253078. Epub 2016 Nov 7.
The present study was designed to investigate the chemical constituents of Lindera nacusua and their antitumor activities. A new phenolic glycoside, namely 1-O-3-hydroxyphenyl-5-methoxyphenol-(6'-O-vanilloyl)-β-d-glucopyranoside (1), together with five known phenolic glycosides (2-6), two anthraquinones (7, 8) and two γ-butanolides (9, 10), was isolated, and its structure was elucidated by spectroscopic and chemical methods. Compounds 1-10 were screened for their in vitro cytotoxicities against HL-60, SMMC-7721, A549, MCF-3 and SW480 cell lines by the MTS method. Compounds 9 and 10 showed moderate cytotoxicities with IC values ranging from 17.40 to 35.21 μM.
本研究旨在研究乌药的化学成分及其抗肿瘤活性。分离得到一种新的酚苷，即1-O-3-羟基苯基-5-甲氧基苯酚-(6'-O-香草酰基)-β-D-吡喃葡萄糖苷(1)，以及五种已知的酚苷(2-6)、两种蒽醌(7,8)和两种γ-丁内酯(9,10)，并通过光谱和化学方法阐明了其结构。采用MTS法筛选化合物1-10对HL-60、SMMC-7721、A549、MCF-3和SW480细胞系的体外细胞毒性。化合物9和10表现出中等细胞毒性，IC值范围为17.40至35.21μM。
Zotero 插件