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多哥洛美因猪链球菌引起的人类脑膜炎:一例报告。

Human meningitis due to Streptococcus suis in Lomé, Togo: a case report.

作者信息

Prince-David Mireille, Salou Mounerou, Marois-Créhan Corinne, Assogba Komi, Plainvert Céline, Balogou Koffi A, Poyart Claire, Tazi Asmaa

机构信息

Centre de Biologie Moléculaire et d'Immunologie, Université de Lomé, BP 101, Lomé, Togo.

Service de Microbiologie, Centre Hospitalier Universitaire Sylvanus Olympio, Tokoin Hôpital, BP 57, Lomé, Togo.

出版信息

BMC Infect Dis. 2016 Nov 8;16(1):651. doi: 10.1186/s12879-016-2006-0.

Abstract

BACKGROUND

Streptococcus suis is a zoonotic pathogen which represents the leading cause of meningitis in Southeast Asia and an emerging pathogen in the Western world, the main risk factor for infection being contact with pigs. In Africa, the prevalence of S. suis infections in swine and humans is largely unrecognized, with only one recent report of a limited case series.

CASE PRESENTATION

We describe a human case of meningitis due to S. suis in a 32-year-old man living in Togo. The patient had no particular medical history and no risk factors for immunodeficiency but reported regular contact with pork products. Using specific immunological and molecular methods, we characterized the isolate as S. suis serotype 2, ST1, one the most prevalent and virulent clone worldwide. The outcome was favorable after one week of adapted antibiotic therapy but the patient was left with severe hearing disorders.

CONCLUSIONS

This work highlights the emergence of this pathogen in Africa and reinforces the need for accurate epidemiological and surveillance studies of S. suis infections and for educating clinicians and exposed groups in non-endemic countries.

摘要

背景

猪链球菌是一种人畜共患病原体,是东南亚地区脑膜炎的主要病因,在西方世界则是一种新出现的病原体,感染的主要风险因素是与猪接触。在非洲,猪和人类中猪链球菌感染的流行情况很大程度上未被认识,近期仅有一份关于有限病例系列的报告。

病例介绍

我们描述了一名居住在多哥的32岁男性因猪链球菌引起的脑膜炎病例。该患者无特殊病史,也无免疫缺陷风险因素,但报告称经常接触猪肉制品。我们使用特定的免疫学和分子方法,将分离株鉴定为猪链球菌2型,ST1,这是全球最普遍且最具毒性的克隆之一。经过一周的适应性抗生素治疗后,结果良好,但患者仍患有严重的听力障碍。

结论

这项工作凸显了这种病原体在非洲的出现,并强化了对猪链球菌感染进行准确的流行病学和监测研究以及对非流行国家的临床医生和暴露人群进行教育的必要性。

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