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Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide.

作者信息

Miller Marina, Rosenthal Peter, Beppu Andrew, Gordillo Ruth, Broide David H

机构信息

Department of Medicine, University of California San Diego, La Jolla, Calif.

Internal Medicine, Touchstone Diabetes Center, the University of Texas Southwestern Medical Center, Dallas, Tex.

出版信息

J Allergy Clin Immunol. 2017 Apr;139(4):1373-1376.e4. doi: 10.1016/j.jaci.2016.08.053. Epub 2016 Nov 5.

Abstract
摘要

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本文引用的文献

1
Effect of pioglitazone on plasma ceramides in adults with metabolic syndrome.
Diabetes Metab Res Rev. 2015 Oct;31(7):734-44. doi: 10.1002/dmrr.2662. Epub 2015 Jun 17.
3
ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.
J Lipid Res. 2015 Apr;56(4):898-908. doi: 10.1194/jlr.M057539. Epub 2015 Feb 17.
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ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.
J Immunol. 2014 Apr 15;192(8):3475-87. doi: 10.4049/jimmunol.1303047. Epub 2014 Mar 12.
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Sphingolipids and susceptibility to asthma.
N Engl J Med. 2013 Sep 5;369(10):976-8. doi: 10.1056/NEJMcibr1306864.
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Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.
Sci Transl Med. 2013 May 22;5(186):186ra67. doi: 10.1126/scitranslmed.3005765.
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ORMDL3 modulates store-operated calcium entry and lymphocyte activation.
Hum Mol Genet. 2013 Feb 1;22(3):519-30. doi: 10.1093/hmg/dds450. Epub 2012 Oct 25.
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ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16648-53. doi: 10.1073/pnas.1204151109. Epub 2012 Sep 24.
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