Sousa Aline Soares de, Cardoso José Carlos, Gouveia Miguel Pinto, Gameiro Ana Rita, Teixeira Vera Barreto, Gonçalo Maria
Complexo Hospitalar Padre Bento de Guarulhos - Guarulhos (SP), Brazil.
Hospital Universitário de Coimbra - Coimbra, Portugal.
An Bras Dermatol. 2016 Sep-Oct;91(5):652-654. doi: 10.1590/abd1806-4841.20164301.
Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib. Lesional patch testing with etoricoxib was positive and reproduced the typical pattern of a fixed drug eruption upon histopathology. We emphasize the specific reactivity of the etoricoxib patch test, and the capacity to reproduce the histologic pattern of the reaction.
非甾体类抗炎药，其次是抗生素，是固定性药疹的主要病因。它们会引发一个或多个圆形红斑或水疱性损害，在服用致病药物后会在同一部位复发。对残留的皮损进行斑贴试验呈阳性可令人满意地替代口服激发试验。我们描述了一名74岁女性的病例，其躯干有许多圆形红斑性损害，右手第五指反复出现水疱，这些症状在服用依托考昔后数小时出现。用依托考昔进行皮损斑贴试验呈阳性，且在组织病理学上再现了固定性药疹的典型模式。我们强调依托考昔斑贴试验的特异性反应性以及再现反应组织学模式的能力。
