Tianjin Huanhu Hospital, No. 6 Jizao Road, Jinnan District, Tianjin, 300350, China.
Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, No. 122, Munan Road, Tianjin, 300050, China; Graduate School of Tianjin Medical University, Tianjin, China.
Chem Biol Interact. 2017 Jan 5;261:11-17. doi: 10.1016/j.cbi.2016.10.020. Epub 2016 Nov 8.
Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear. Here, we show that naringin promotes fracture healing through stimulating angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.
绝经后骨质疏松症的特征是骨髓窦状和动脉毛细血管数量减少以及骨灌注减少。因此，成骨和血管生成在骨质疏松形成和骨折愈合过程中是耦联的。柚皮苷是中药骨碎补的主要成分，具有促进骨折愈合的潜在作用。然而，柚皮苷在骨愈合过程中是否刺激血管生成尚不清楚。在这里，我们通过调节骨质疏松大鼠的 VEGF/VEGFR-2 信号通路显示，柚皮苷通过刺激血管生成促进骨折愈合。
