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骨碎补巴布剂对去卵巢骨质疏松大鼠骨折愈合的影响

Effects of Rhizoma Drynariae Cataplasm on Fracture Healing in a Rat Model of Osteoporosis.

机构信息

Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).

出版信息

Med Sci Monit. 2019 Apr 28;25:3133-3139. doi: 10.12659/MSM.914568.

DOI:10.12659/MSM.914568
PMID:31030207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6503747/
Abstract

BACKGROUND Osteoporosis is an increasingly prevalent disease characterized by decreased bone mass and deterioration of the bone microstructure, which contribute to increased fragility and subsequent fragility fractures, especially in elderly individuals. Rhizoma Drynariae (DRE) is among the most frequently used herbal medicines for the treatment of osteoporosis. Transdermal delivery is a proven novel pathway for drug treatment and has several advantages over traditional drug delivery routes. MATERIAL AND METHODS Female Sprague-Dawley osteoporotic fracture model rats were divided into 3 groups: the control group, the DRE (90 mg/kg/day) group and the DRE cataplasm (containing 30 mg DRE, administered at right femur site daily) group. At 3 and 6 weeks after operation, we performed x-ray, histological, and biomechanical analyses, and evaluated bone marrow density of the femur. RESULTS Treatment with DRE increased callus formation and bone union compared with the control group. Moreover, DRE enhanced bone strength at the femoral diaphysis in the osteoporotic fractures in rats by increasing the ultimate load and stiffness compared with the control group. Furthermore, DRE restored the trabecular bone mineral density in the femur compared with the control group. DRE cataplasm application further enhanced the therapeutic effects against osteoporotic fracture in this rat model. CONCLUSIONS DRE cataplasm application might be useful against osteoporotic fracture.

摘要

背景

骨质疏松症是一种日益普遍的疾病，其特征是骨量减少和骨微观结构恶化，导致脆性增加，随后发生脆性骨折，尤其是在老年人中。骨碎补是治疗骨质疏松症最常用的草药之一。经皮给药是一种已被证实的新型药物治疗途径，相对于传统的药物输送途径具有多个优势。

材料和方法

雌性 Sprague-Dawley 骨质疏松性骨折模型大鼠分为 3 组：对照组、骨碎补（90mg/kg/天）组和骨碎补巴布剂（每天在右股骨部位给予含 30mg 骨碎补的巴布剂）组。术后 3 周和 6 周时，进行 X 射线、组织学和生物力学分析，并评估股骨骨髓密度。

结果

与对照组相比，骨碎补治疗可增加骨痂形成和骨愈合。此外，与对照组相比，骨碎补通过增加最大载荷和刚度增强了大鼠骨质疏松性骨折骨干的骨强度。此外，骨碎补恢复了股骨的小梁骨矿物质密度。与对照组相比，骨碎补巴布剂的应用进一步增强了对该大鼠模型中骨质疏松性骨折的治疗效果。

结论

骨碎补巴布剂的应用可能对骨质疏松性骨折有用。

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Drug Des Devel Ther. 2018 Dec 13;12:4231-4240. doi: 10.2147/DDDT.S187177. eCollection 2018.
2
Enhanced transdermal lymphatic delivery of doxorubicin via hyaluronic acid based transfersomes/microneedle complex for tumor metastasis therapy.基于透明质酸的传递体/微针复合体系增强阿霉素经皮淋巴递药用于肿瘤转移治疗。
Int J Biol Macromol. 2019 Mar 15;125:9-16. doi: 10.1016/j.ijbiomac.2018.11.230. Epub 2018 Nov 27.
3
Gukang Capsule Promotes Fracture Healing by Activating BMP/SMAD and Wnt/-Catenin Signaling Pathways.
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Evid Based Complement Alternat Med. 2020 Sep 29;2020:7184502. doi: 10.1155/2020/7184502. eCollection 2020.
4
A study of Drynaria fortunei in modulation of BMP–2 signalling by bone tissue engineering.一项关于密鳞骨碎补通过骨组织工程调节 BMP-2 信号的研究。
Turk J Med Sci. 2020 Aug 26;50(5):1444-1453. doi: 10.3906/sag-2001-148.
5
The Antiosteoporosis Effects of Yishen Bugu Ye Based on Its Regulation on the Differentiation of Osteoblast and Osteoclast.基于益肾补骨液对成骨细胞和破骨细胞分化的调节作用探讨其抗骨质疏松的作用。
Biomed Res Int. 2020 Feb 19;2020:9467683. doi: 10.1155/2020/9467683. eCollection 2020.
Correlations of Serum Hormones and Bone Mineral Density with Fracture and Balance Ability of Postmenopausal Patients and Effects of Calcitriol.
血清激素与骨密度与绝经后患者骨折和平衡能力的相关性及骨化三醇的作用。
Med Sci Monit. 2018 Oct 13;24:7309-7315. doi: 10.12659/MSM.910792.
4
Association of Bone Morphogenetic Protein (BMP)/Smad Signaling Pathway with Fracture Healing and Osteogenic Ability in Senile Osteoporotic Fracture in Humans and Rats.骨形态发生蛋白（BMP）/Smad 信号通路与人类和大鼠老年骨质疏松性骨折愈合及成骨能力的关系。
Med Sci Monit. 2018 Jun 25;24:4363-4371. doi: 10.12659/MSM.905958.
5
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6
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7
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Exp Ther Med. 2017 May;13(5):2399-2404. doi: 10.3892/etm.2017.4233. Epub 2017 Mar 17.
8
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J Tradit Chin Med. 2016 Aug;36(4):464-70. doi: 10.1016/s0254-6272(16)30063-2.
9
Long-term hormone therapy for perimenopausal and postmenopausal women.围绝经期和绝经后女性的长期激素治疗
Cochrane Database Syst Rev. 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5.
10
Naringin promotes osteogenic differentiation of bone marrow stromal cells by up-regulating Foxc2 expression via the IHH signaling pathway.柚皮苷通过IHH信号通路上调Foxc2表达促进骨髓基质细胞的成骨分化。
Am J Transl Res. 2016 Nov 15;8(11):5098-5107. eCollection 2016.