Li Haotao, Wu Rongjie, Yu Haiyang, Zheng Qiujian, Chen Yuanfeng
Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Shantou University Medical College, Shantou, China.
Front Pharmacol. 2021 Oct 28;12:778041. doi: 10.3389/fphar.2021.778041. eCollection 2021.
Traditional Chinese medicine (TCM) has demonstrated superior therapeutic effect for musculoskeletal diseases for thousands of years. Recently, the herbal extracts of TCM have received rapid advances in musculoskeletal tissue engineering (MTE). A literature review collecting both English and Chinese references on bioactive herbal extracts of TCM in biomaterial-based approaches was performed. This review provides an up-to-date overview of application of TCMs in the field of MTE, involving regulation of multiple signaling pathways in osteogenesis, angiogenesis, anti-inflammation, and chondrogenesis. Meanwhile, we highlight the potential advantages of TCM, opening the possibility of its extensive application in MTE. Overall, the superiority of traditional Chinese medicine turns it into an attractive candidate for coupling with advanced additive manufacturing technology.
数千年来，传统中医（TCM）在治疗肌肉骨骼疾病方面展现出卓越的疗效。近年来，中药提取物在肌肉骨骼组织工程（MTE）领域取得了快速进展。我们进行了一项文献综述，收集了中英文关于基于生物材料方法的中药生物活性提取物的参考文献。本综述提供了中药在MTE领域应用的最新概述，涉及成骨、血管生成、抗炎和软骨生成中多种信号通路的调节。同时，我们强调了中药的潜在优势，为其在MTE中的广泛应用开辟了可能性。总体而言，传统中医的优越性使其成为与先进增材制造技术相结合的有吸引力的候选者。
