Lafage M, Maroc N, Dubreuil P, de Waal Malefijt R, Pébusque M J, Carcassonne Y, Mannoni P
Department of Hematology and Cell Biology, Regional Cancer Center, Marseille, France.
Blood. 1989 Jan;73(1):104-7.
Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which was described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors. In this report we discuss our use of in situ hybridization on human prometaphase cells with a human IL-1 alpha cDNA probe to localize the human IL-1 alpha gene on the proximal part of the long arm of chromosome 2 at band q13, in the same chromosomal region as the IL-1 beta gene.
白细胞介素-1α（IL-1α）和白细胞介素-1β（IL-1β）是两种生物化学性质不同但关系较远的多肽细胞因子，它们在炎症、免疫反应和组织修复中起关键作用。最近，研究表明IL-1α与造血素1相同，造血素1被描述为一种造血生长因子，可与其他造血生长因子协同作用于早期祖细胞。在本报告中，我们讨论了使用人IL-1α cDNA探针在人早中期细胞上进行原位杂交，将人IL-1α基因定位在2号染色体长臂近端q13带，与IL-1β基因位于同一染色体区域。
