Gheorghe Dorin Nicolae, Popescu Dora Maria, Dinescu Stefan Cristian, Silaghi Margarita, Surlin Petra, Ciurea Paulina Lucia
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Periodontology, Research Center of Periodontal-Systemic Interactions, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Diagnostics (Basel). 2023 Apr 12;13(8):1401. doi: 10.3390/diagnostics13081401.
In recent decades, researchers have investigated the bidirectional links between periodontal disease and systemic diseases, and the results have allowed the development of the concept of periodontal medicine. This concept incorporates and analyzes the mutually influential interactions that can occur between periodontitis and systemic diseases such as diabetes mellitus or cardiovascular diseases. Sjögren's syndrome (SS) is a chronic autoimmune disorder that targets the exocrine glands of the body, such as the lacrimal and salivary glands. The amount of saliva produced may gradually decrease with the progression of the disease, which can have an impact on the structures within the oral cavity. Although the reduction in saliva flow produces negative effects in the oral cavity, a direct association between Sjögren's syndrome and periodontal disease has not yet been demonstrated. Available studies on this topic have not identified significant differences in the periodontal status of patients with Sjögren's syndrome and control groups at the clinical and bacteriological levels. On the other hand, other studies on this topic consider that patients with periodontitis have a higher risk of developing Sjögren's syndrome than the general population. Therefore, the results remain inconclusive, highlighting the need for further complementary studies.
近几十年来，研究人员对牙周疾病与全身性疾病之间的双向联系进行了调查，这些结果促使了牙周医学概念的发展。这一概念纳入并分析了牙周炎与糖尿病或心血管疾病等全身性疾病之间可能发生的相互影响的相互作用。干燥综合征（SS）是一种慢性自身免疫性疾病，其靶器官为人体的外分泌腺，如泪腺和唾液腺。随着疾病的进展，唾液分泌量可能会逐渐减少，这会对口腔内的结构产生影响。尽管唾液分泌减少会在口腔内产生负面影响，但干燥综合征与牙周疾病之间的直接关联尚未得到证实。关于这一主题的现有研究在临床和细菌学水平上并未发现干燥综合征患者与对照组在牙周状况上存在显著差异。另一方面，关于这一主题的其他研究认为，牙周炎患者患干燥综合征的风险高于普通人群。因此，结果尚无定论，这突出表明需要进一步开展补充性研究。
