兔鼻窦炎模型中骨炎的计算机断层扫描及组织病理学评估

Computed tomography and histopathological evaluation of osteitis in rabbit models with rhinosinusitis.

作者信息

Dong Yi, Zhou Bing, Wang Xiangdong, Huang Zhenxiao, Wang Mingjie, Li Yunchuan, Zang Hongrui, Fan Erzhong, Li Ying, Wang Xinyan

机构信息

a Department of Otolaryngology Head and Neck Surgery , Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education , Beijing , PR China.

b Beijing Institute of Otolaryngology , Beijing , PR China.

出版信息

Acta Otolaryngol. 2017 May;137(5):534-540. doi: 10.1080/00016489.2016.1252060. Epub 2016 Nov 11.

DOI:10.1080/00016489.2016.1252060

PMID:27834111

Abstract

CONCLUSIONS

There is clear correspondence between HU and histopathological evaluation of osteitis. It is feasible to evaluate bone remodeling in rabbit models with rhinosinusitis by measuring the HU.

OBJECTIVE

The objective of this study was to determine whether the HUs of rabbit CRS models can be used to objectively evaluate the degree of osteitis.

METHODS

Sixty rabbit models were inoculated with staphylococcus aureus. The rabbits were divided into three groups. Each group was divided into a medication administration team and a control team. The HU of the bone in each image was measured. All of the animals were executed after the CT exam. The samples for the mucous and bone changes using light microscope observation were scored. These scores and the HU measurements were compared to the actual bone remodeling over time to examine whether we could evaluate bone remodeling by measuring the HU.

RESULTS

The average HU scores in Groups A, B, and C were significantly higher than those of normal rabbits (p < .05). The mucous and bone scores increased as the experimental period lengthened (p = .042, 0.002). HU correlated with the mucous and bone scores in rabbit models with rhinosinusitis (coefficient r = .830, 0.641, 0.586, p = .000).

摘要