Amaratunga N A
Division of Oral Surgery, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
J Oral Maxillofac Surg. 1989 Jan;47(1):7-10. doi: 10.1016/0278-2391(89)90115-8.
Fifty-eight infants with cleft lip and/or cleft palate detected in a prospective study and 443 cleft patients in a retrospective study were investigated regarding seasonal variation of incidence, relation to birth rank, consanguinity of parents, and history of viral infections and drugs taken by mothers during the first trimester of gestation. The highest incidence was recorded in the month of April, but no reason for this could be found. No significant relation to birth rank and consanguinity of parents existed. Furthermore, the proportion of mothers of cleft patients who had taken drugs or who had viral infections was not significantly greater than in the control groups. These findings support the view that orofacial clefts probably have a multifactorial etiology.
在一项前瞻性研究中检测出58例唇裂和/或腭裂婴儿，并对一项回顾性研究中的443例腭裂患者进行了调查，内容涉及发病率的季节变化、与出生顺序的关系、父母的血缘关系以及母亲在妊娠头三个月期间的病毒感染史和用药史。4月份的发病率最高，但未找到对此的解释。未发现与出生顺序和父母血缘关系存在显著关联。此外，腭裂患者母亲中服用药物或患有病毒感染的比例并不显著高于对照组。这些发现支持了口面部裂隙可能具有多因素病因的观点。
