评估唇腭裂的母体和父体年龄、出生顺序和孕次间隔。
Maternal and paternal age, birth order and interpregnancy interval evaluation for cleft lip-palate.
机构信息
Universidade estadual de Montes Claros, Brazil.
出版信息
Braz J Otorhinolaryngol. 2010 Jan-Feb;76(1):107-12. doi: 10.1590/S1808-86942010000100018.
UNLABELLED
Cleft lip and palate (CL/P) are the most common congenital craniofacial anomalies.
AIM
To evaluate environmental risk factors for non-syndromic CL/P in a reference care center in Minas Gerais.
MATERIALS AND METHODS
we carried out a case-controlled study, assessing 100 children with clefts and 100 children without clinical alterations. The analysis dimensions (age, skin color, gender, fissure classification, maternal and paternal age, birth order and interpregnancy interval), obtained from a questionnaire; and later we build a data base and the analyses were carried out by the SPSS 17.0 software. The results were analyzed with the relative risk for each variable, in order to estimate the odds ratio with a 95% confidence interval, followed by a bivariate and multivariate analysis.
RESULTS
among 200 children, 54% were males and 46% were females. As far as skin color is concerned most were brown, white and black, respectively. Cleft palates were the most common fissures found (54%), followed by lip cleft (30%) and palate cleft (16%).
CONCLUSION
although with a limited sample, we noticed an association between maternal age and an increased risk for cleft lip and palate; however, paternal age, pregnancy order and interpregnancy interval were not significant.
目的
在米纳斯吉拉斯州的一个参考护理中心评估非综合征性唇腭裂（CL/P）的环境风险因素。
方法
我们进行了一项病例对照研究，评估了 100 例唇裂和腭裂患儿和 100 例无临床改变的患儿。通过问卷获得分析维度（年龄、肤色、性别、裂隙分类、母亲和父亲的年龄、出生顺序和产次间隔）；然后我们建立了一个数据库，使用 SPSS 17.0 软件进行分析。通过对每个变量的相对风险进行分析，以估计比值比及其 95%置信区间，然后进行单变量和多变量分析。
结果
在 200 名儿童中，54%为男性，46%为女性。就肤色而言，棕色、白色和黑色分别最为常见。最常见的裂隙是腭裂（54%），其次是唇裂（30%）和腭裂（16%）。
结论
尽管样本有限，但我们注意到母亲年龄与唇腭裂风险增加之间存在关联；然而，父亲年龄、妊娠顺序和产次间隔没有显著影响。
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