Lally E V, Zimmermann B, Ho G, Kaplan S R
Department of Medicine, Roger Williams General Hospital, Rhode Island Hospital, Providence 02903.
Arthritis Rheum. 1989 Jan;32(1):86-90. doi: 10.1002/anr.1780320115.
We studied 25 patients with crystal-proven gout or roentgenographic evidence of gouty arthritis, or both, in finger joints involved with nodal osteoarthritis (OA). These patients were elderly (mean age 71.4 years), and 72% of them were receiving diuretic therapy. Roentgenographic findings, in addition to features typical of OA, included soft tissue densities (tophi), with or without calcification, large intraarticular erosions, characteristic nonmarginal cortical erosions, and periarticular osteolysis. We conclude that urate crystals mediate episodes of acute inflammation in certain patients with nodal OA. This association is noted primarily in elderly patients of both sexes, especially in those receiving diuretic therapy.
我们研究了25例经晶体证实患有痛风或有痛风性关节炎的X线证据，或两者皆有，且手指关节患有结节性骨关节炎（OA）的患者。这些患者均为老年人（平均年龄71.4岁），其中72%正在接受利尿治疗。除OA的典型特征外，X线表现还包括软组织密度影（痛风石），有或无钙化，大的关节内侵蚀，特征性的非边缘性皮质侵蚀以及关节周围骨质溶解。我们得出结论，尿酸盐晶体介导了某些结节性OA患者的急性炎症发作。这种关联主要见于老年男女患者，尤其是正在接受利尿治疗的患者。
