Ma Cheryl Ann, Leung Ying Ying
Duke-NUS Medical School, Singapore, Singapore.
Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore.
Front Med (Lausanne). 2017 Dec 13;4:225. doi: 10.3389/fmed.2017.00225. eCollection 2017.
Both gout and osteoarthritis (OA) are common forms of arthritis that inflict a huge burden to an aging population with the increasing prevalence of obesity. Clinicians have long observed the link between these two conditions. In this review, we summarize the evidence from epidemiologic and immunological studies that described the possible relationship between the two conditions. The recent new understanding on monosodium uric acid crystal-induced inflammation has given insight into probable shared pathogenesis pathways for both conditions. We describe the potential therapeutic implications, particularly regarding the possibility of repurposing traditional gout medications for use in OA.
痛风和骨关节炎（OA）都是常见的关节炎形式，随着肥胖患病率的上升，给老龄化人口带来了巨大负担。临床医生早就观察到了这两种病症之间的联系。在本综述中，我们总结了流行病学和免疫学研究的证据，这些证据描述了这两种病症之间可能的关系。最近对尿酸单钠晶体诱导炎症的新认识为这两种病症可能的共同发病机制途径提供了见解。我们描述了潜在的治疗意义，特别是关于将传统痛风药物重新用于骨关节炎治疗的可能性。
