拉曼光谱法应用于尿酸钠晶体沉积物的无创检测

Curran Declan J, Rubin Laurence, Towler Mark R

Department of Mechanical and Industrial Engineering, Ryerson University, Toronto, ON, Canada.

Division of Rheumatology, St. Michael's Hospital, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Clin Med Insights Arthritis Musculoskelet Disord. 2015 Aug 18;8:55-8. doi: 10.4137/CMAMD.S29061. eCollection 2015.

An off-the-shelf Raman Spectrometer (RS) was used to noninvasively determine the presence of monosodium urate (MSU) crystals on the metatarsophalangeal joint (MTPJ) of a single gout sufferer. The spectrum sourced from the clinically diagnosed gout sufferer was compared to that sourced from an age-matched healthy subject scanned using the same protocol. Minimal signal processing was conducted on both spectra. Peaks characteristic of MSU crystals were evident on the spectrum sourced from the gout sufferer and not on the spectrum from the healthy control.

使用一台现成的拉曼光谱仪（RS）对一名痛风患者的跖趾关节（MTPJ）进行无创检测，以确定尿酸钠（MSU）晶体的存在。将临床诊断为痛风患者的光谱与按照相同方案扫描的年龄匹配的健康受试者的光谱进行比较。对两个光谱都进行了最少的信号处理。在痛风患者的光谱上明显出现了MSU晶体的特征峰，而在健康对照的光谱上则没有。