Basso Lilian, Altier Christophe
Department of Physiology and Pharmacology, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada.
Department of Physiology and Pharmacology, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada.
Curr Opin Pharmacol. 2017 Feb;32:9-15. doi: 10.1016/j.coph.2016.10.002. Epub 2016 Oct 27.
Neuropathic pain caused by disease or dysfunction of the nervous system is one of the most difficult pain conditions to treat. Symptoms include a hypersensitivity to mechanical and thermal stimuli, processed by specialized nociceptors that constitute the first line of defence of the somatosensory system. The detection of these stimuli depends on the TRP ion channel family, which activates upon damaging pressure, extreme temperature, or toxic endogenous and exogenous chemicals. This review will summarize the current knowledge of the contribution of TRP channels, particularly the thermosensitive TRP, including TRPV1, TRPA1 and TRPM8 channels that play a central role in the sensitization of nociceptive transduction. We will discuss the pharmacology of these receptors and their relative success in preclinical and clinical studies.
由神经系统疾病或功能障碍引起的神经性疼痛是最难治疗的疼痛病症之一。症状包括对机械和热刺激的超敏反应，这些刺激由构成躯体感觉系统第一道防线的特殊伤害感受器进行处理。这些刺激的检测取决于TRP离子通道家族，该家族在受到损伤性压力、极端温度或有毒内源性和外源性化学物质刺激时被激活。本综述将总结目前关于TRP通道，特别是热敏TRP通道（包括在伤害性转导敏化中起核心作用的TRPV1、TRPA1和TRPM8通道）作用的认识。我们将讨论这些受体的药理学及其在临床前和临床研究中的相对成效。
