MyTH4-FERM肌球蛋白在基于肌动蛋白的突起的组装和维持中发挥作用。
MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.
作者信息
Weck Meredith L, Grega-Larson Nathan E, Tyska Matthew J
机构信息
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States.
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 3154 MRB III, PMB 407935, 465 21st Avenue South, Nashville, TN 37240-7935, United States.
出版信息
Curr Opin Cell Biol. 2017 Feb;44:68-78. doi: 10.1016/j.ceb.2016.10.002. Epub 2016 Nov 9.
Unconventional myosins are actin-based molecular motors that serve a multitude of roles within the cell. One group of myosin motors, the MyTH4-FERM myosins, play an integral part in building and maintaining finger-like protrusions, which allow cells to interact with their external environment. Suggested to act primarily as transporters, these motor proteins enrich adhesion molecules, actin-regulatory proteins and other factors at the tips of filopodia, microvilli, and stereocilia. Below we review data from biophysical, biochemical, and cell biological studies, which implicate these myosins as central players in the assembly, maintenance and function of actin-based protrusions.
非常规肌球蛋白是基于肌动蛋白的分子马达，在细胞内发挥多种作用。其中一组肌球蛋白马达，即MyTH4-FERM肌球蛋白，在构建和维持手指状突起中发挥着不可或缺的作用，这些突起使细胞能够与外部环境相互作用。这些马达蛋白主要作为转运蛋白，在丝状伪足、微绒毛和静纤毛的尖端富集粘附分子、肌动蛋白调节蛋白和其他因子。下面我们回顾来自生物物理、生物化学和细胞生物学研究的数据，这些数据表明这些肌球蛋白是基于肌动蛋白的突起的组装、维持和功能的核心参与者。
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