Karakaş Nazmi Mutlu, Tulgar Kınık Sibel, Özdemir Beril, Muratoğlu Şahin Nursel, Tekindal M Ağah, Haberal Ayşegül
Başkent University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey, Phone: +90 530 3301977 E-mail:
J Clin Res Pediatr Endocrinol. 2017 Jun 1;9(2):106-110. doi: 10.4274/jcrpe.3532. Epub 2016 Nov 9.
The present study aimed to evaluate the biochemical markers of bone turnover in children with congenital hypothyroidism during the course of treatment as compared to healthy children selected as controls.
The study included 31 children with congenital hypothyroidism and 29 healthy children. In both groups, we evaluated serum procollagen type-1 N-terminal propeptide (PINP) and tartrate-resistant acid phosphatase type 5b isoform (TRACP 5b) levels as bone turnover markers.
In both groups, thyroid hormone levels were within normal limits. The levels of vitamin D were significantly higher in the cases with congenital hypothyroidism. Although PINP levels were not found to be different, TRACP 5b levels which are related to osteoclastic activities were significantly higher in the control group.
We did not detect an increase in bone resorption in patients with congenital hypothyroidism, despite long-term treatment with LT4. Our results suggest that with effective vitamin D treatment and thyroxin replacement, congenital hypothyroidism is not a deleterious factor for bone turnover.
本研究旨在评估先天性甲状腺功能减退症患儿在治疗过程中骨转换的生化标志物，并与作为对照的健康儿童进行比较。
该研究纳入了31例先天性甲状腺功能减退症患儿和29例健康儿童。在两组中，我们评估了血清1型前胶原N端前肽（PINP）和抗酒石酸酸性磷酸酶5b同工酶（TRACP 5b）水平作为骨转换标志物。
两组的甲状腺激素水平均在正常范围内。先天性甲状腺功能减退症患儿的维生素D水平显著更高。尽管未发现PINP水平存在差异，但与破骨细胞活性相关的TRACP 5b水平在对照组中显著更高。
尽管先天性甲状腺功能减退症患者长期接受左甲状腺素（LT4）治疗，但我们并未检测到其骨吸收增加。我们的结果表明，通过有效的维生素D治疗和甲状腺素替代治疗，先天性甲状腺功能减退症并非骨转换的有害因素。
