Cooper C, Mclaren M, Wood P J, Coulton L, Kanis J A
MRC Environmental Epidemiology Unit, Southampton General Hospital, England.
Bone Miner. 1989 Jan;5(2):193-200. doi: 10.1016/0169-6009(89)90096-2.
We have assessed indices of calcium metabolism in 41 women with hip fractures and compared them with two elderly control groups. The women with hip fractures had lower serum concentrations of albumin, 25-hydroxyvitamin D and osteocalcin than the controls. Serum concentrations of calcium, alkaline phosphatase and parathyroid hormone, as well as urinary hydroxyproline/creatinine ratios were similar in the three groups of women. The small reduction in serum osteocalcin concentration in fracture patients is consistent with the hypothesis that reduced osteoblast function may contribute to the osteoporosis which results in hip fracture.
我们评估了41名髋部骨折女性的钙代谢指标，并将其与两个老年对照组进行了比较。髋部骨折女性的血清白蛋白、25-羟基维生素D和骨钙素浓度低于对照组。三组女性的血清钙、碱性磷酸酶和甲状旁腺激素浓度以及尿羟脯氨酸/肌酐比值相似。骨折患者血清骨钙素浓度的小幅降低与以下假设一致，即成骨细胞功能降低可能导致骨质疏松，进而导致髋部骨折。
