药物性肝毒性的流行病学及遗传危险因素
Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity.
作者信息
Ahmad Jawad, Odin Joseph A
机构信息
Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1104, New York, NY 10029, USA.
Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1104, New York, NY 10029, USA.
出版信息
Clin Liver Dis. 2017 Feb;21(1):55-72. doi: 10.1016/j.cld.2016.08.004. Epub 2016 Oct 14.
Abstract
Idiosyncratic drug-induced liver injury (DILI) from prescription medications and herbal and dietary supplements has an annual incidence rate of approximately 20 cases per 100,000 per year. However, the risk of DILI varies greatly according to the drug. In the United States and Europe, antimicrobials are the commonest implicated agents, with amoxicillin/clavulanate the most common, whereas in Asian countries, herbal and dietary supplements predominate. Genetic analysis of DILI is currently limited, but multiple polymorphisms of human leukocyte antigen genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI.
摘要
由处方药以及草药和膳食补充剂引起的特异质性药物性肝损伤（DILI）的年发病率约为每10万人每年20例。然而，DILI的风险因药物而异。在美国和欧洲，抗菌药物是最常见的相关药物，阿莫西林/克拉维酸最为常见，而在亚洲国家，草药和膳食补充剂占主导地位。目前对DILI的基因分析有限，但人类白细胞抗原基因以及参与药物代谢和转运的基因的多种多态性已被确定为DILI的风险因素。
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