无菌动物被肠道克罗恩病组织污染。初步报告。
Contamination of germfree animals with intestinal Crohn tissue. A preliminary report.
作者信息
Bergstrand O, Holmström B, Gustafsson B E
出版信息
Acta Chir Scand Suppl. 1978;482:48-50.
PMID:278428
Abstract
The preliminary results of one of a series of prospective studies in the investigation of a possible transmissible agent in Crohn's disease are presented. Filtered human Crohn tissue homogenates was inoculated into eight germfree Sprague-Dawley rats, to test the reproducibility of recent reports suggesting a transmissible agent in regional ileitis. No histological changes were evident after 150 days, and no changes were observed in animals inoculated with non-Crohn tissue homogenates.
摘要
本文展示了一系列前瞻性研究中的一项初步结果，该研究旨在调查克罗恩病中可能存在的一种可传播病原体。将经过滤的人类克罗恩病组织匀浆接种到八只无菌的斯普拉格-道利大鼠体内，以检验最近有关局限性回肠炎中存在可传播病原体的报告的可重复性。150天后未发现明显的组织学变化，接种非克罗恩病组织匀浆的动物也未观察到变化。
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Contamination of germfree animals with intestinal Crohn tissue. A preliminary report.无菌动物被肠道克罗恩病组织污染。初步报告。
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