前列腺腺癌的临床分期、自然杀伤细胞活性及相关免疫参数之间的关系。
The relationship between clinical stage, natural killer activity and related immunological parameters in adenocarcinoma of the prostate.
作者信息
Lahat N, Alexander B, Levin D R, Moskovitz B
机构信息
Immunology Research Unit, Lady Davis Carmel Hospital, Haifa, Israel.
出版信息
Cancer Immunol Immunother. 1989;28(3):208-12. doi: 10.1007/BF00204990.
Abstract
Several immunological in vitro tests were performed on peripheral blood mononuclear cells of patients with adenocarcinoma of the prostate, stages A, B, C, D. The cytotoxicity of effector natural killer cells towards K-562 targets decreased with increasing disease spread, while their percentage was not significantly changed. The proportion of CD4 (helper/inducer) cells tended to fall with tumor advance, but the proportion of CD8 (suppressor/cytotoxic) cells remained almost constant. Secretion of interleukin-2 from peripheral blood mononuclear cells was diminished with disease progression. Pretreatment of a patient's lymphocytes with cimetidine (antagonist of H-2-bearing suppressor T cells) or indomethacin (inhibitor of prostaglandin synthesis) enhanced natural killer activity. Our data point to the existence of aberrant immune functions in early stages of carcinoma of the prostate and to aggravation of these immune abnormalities in advanced disease.
摘要
对A、B、C、D期前列腺腺癌患者的外周血单个核细胞进行了多项体外免疫学检测。随着疾病扩散，效应性自然杀伤细胞对K-562靶标的细胞毒性降低，但其百分比无显著变化。CD4（辅助/诱导）细胞比例随肿瘤进展有下降趋势，但CD8（抑制/细胞毒性）细胞比例几乎保持不变。外周血单个核细胞白细胞介素-2的分泌随疾病进展而减少。用西咪替丁（H-2携带抑制性T细胞拮抗剂）或吲哚美辛（前列腺素合成抑制剂）预处理患者淋巴细胞可增强自然杀伤活性。我们的数据表明前列腺癌早期存在异常免疫功能，且在疾病晚期这些免疫异常会加重。
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