基因多态性（rs11792633 C/T）分析与精神分裂症风险
Analysis of gene polymorphism (rs11792633 C/T) and risk of schizophrenia.
作者信息
Kordi-Tamandani Dor Mohammad, Bahrami Ahmad Reza, Sabbaghi-Ghale-No Raziye, Soleimani Hanieh, Baranzehi Tayebe
机构信息
Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
Department of Biology, Ferdowssi University of Mashhad, Mashhad, Iran.
出版信息
Mol Biol Res Commun. 2016 Mar;5(1):45-48.
Recently, inflammation has been found to be a significant factor in the development of Schizophrenia (SCZ). The aim of the present research was to investigate whether interleukin-33 (, OMIM: 608678) gene polymorphism (rs11792633, C/T) is associated with the development of SCZ or not. DNA was isolated from the serum of 70 patients with SCZ and 70 healthy controls. The PCR based method was used for detection of the polymorphism. The CT (OR=0.05, 95% CI: 0.003-0.057, P<0.001) and TT (OR=0.12, 95% CI: 0.028-0.46, P<0.001) genotypes significantly decreased the risk of SCZ. Our present findings indicate that the polymorphism associated with the risk of SCZ.
最近，炎症被发现是精神分裂症（SCZ）发病的一个重要因素。本研究的目的是调查白细胞介素-33（IL-33，OMIM：608678）基因多态性（rs11792633，C/T）是否与SCZ的发病有关。从70例SCZ患者和70例健康对照者的血清中提取DNA。采用基于聚合酶链反应（PCR）的方法检测该多态性。CT（比值比[OR]=0.05，95%置信区间[CI]：0.003 - 0.057，P<0.001）和TT（OR=0.12，95% CI：0.028 - 0.46，P<0.001）基因型显著降低了SCZ的发病风险。我们目前的研究结果表明，该多态性与SCZ的发病风险相关。
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