Clinical Hospital Center Rijeka, Clinic for Gynecology and Obstetrics, Rijeka, Croatia.
Arch Gynecol Obstet. 2024 Oct;310(4):1905-1918. doi: 10.1007/s00404-024-07697-7. Epub 2024 Aug 29.
The prevalence of fibroids during reproductive age is 20-25%. The presence of fibroids during pregnancy can impact perinatal outcomes.
To determine whether fibroids affect perinatal outcomes and whether women who undergo fibroid surgery before pregnancy have better perinatal outcomes than those who have fibroids during pregnancy. The study also analyzes the optimal time interval between myomectomy and pregnancy and the characteristics of fibroids during pregnancy that affect perinatal outcomes. In both groups, fibroids' size, number, and location were analyzed to determine their influence on perinatal outcomes. The perinatal outcome is determined by gestational age, birth weight, Apgar score, intrauterine growth retardation, placental complications, and delivery method.
A study was conducted on the perinatal outcomes of 338 women who had uterine fibroids during pregnancy and those who had undergone fibroid surgery before pregnancy. The medical records of women who gave birth at a tertiary university hospital were analyzed in this retrospective study.
Women with submucosal fibroids have a lower gestational age of delivery (P = 0.0371), and those who operated on a higher number of fibroids before pregnancy had newborns with lower birth weights (P < 0.0001). Submucosal fibroids during pregnancy increase the chances of cesarean delivery (P = 0.0354). 14% of newborns have an Apgar score of less than seven within the first minute of birth in fibroids larger than 7 cm (P < 0.0001).
There is a statistically significant difference in the perinatal outcome of newborns depending on the number, size and placement of uterine fibroids in both observed groups.
生育年龄的子宫肌瘤患病率为 20-25%。怀孕期间子宫肌瘤的存在可能会影响围产期结局。
确定子宫肌瘤是否会影响围产期结局，以及是否在怀孕前进行子宫肌瘤手术的女性比怀孕期间患有子宫肌瘤的女性有更好的围产期结局。本研究还分析了子宫肌瘤切除术与妊娠之间的最佳时间间隔，以及影响围产期结局的妊娠期间子宫肌瘤的特征。在这两组中，分析了子宫肌瘤的大小、数量和位置，以确定它们对围产期结局的影响。围产期结局由胎龄、出生体重、阿普加评分、宫内生长迟缓、胎盘并发症和分娩方式决定。
对在妊娠期间患有子宫肌瘤和在妊娠前进行过子宫肌瘤手术的 338 名妇女的围产期结局进行了研究。这项回顾性研究分析了在一所三级大学医院分娩的妇女的病历。
黏膜下子宫肌瘤患者的分娩胎龄较低（P=0.0371），且在妊娠前进行过更多数量的子宫肌瘤手术的患者，新生儿出生体重较低（P<0.0001）。妊娠期间黏膜下子宫肌瘤增加剖宫产的可能性（P=0.0354）。在子宫肌瘤大于 7cm 的情况下，14%的新生儿在出生后第一分钟的阿普加评分为 7 分以下（P<0.0001）。
根据观察两组中子宫肌瘤的数量、大小和位置，新生儿的围产期结局存在统计学显著差异。
