Roupe G
Acta Derm Venereol Suppl (Stockh). 1978;58(79):65-71.
The effect of adult thymectomy on antibody production and on the development of contact sensitivity to picryl chloride in mice of different ages was studied. An age-dependent decline in the ability to develop contact sensitivity was found to be counteracted by thymectomy. In contrast, antibody production was regularly decreased by thymectomy in mice of all ages. The results suggest that the development of contact sensitivity is regulated by long-lived thymus-dependent suppressor cells which do not affect antibody formation. In addition, the effect of antibody and of lysolecithin-analogues on the development of contact sensitivity is reported.
研究了成年小鼠胸腺切除对不同年龄小鼠抗体产生及对苦味酸氯接触敏感性发展的影响。发现胸腺切除可抵消接触敏感性发展能力随年龄的下降。相反，胸腺切除在所有年龄的小鼠中均会使抗体产生规律性减少。结果表明，接触敏感性的发展受长寿的胸腺依赖性抑制细胞调节，这些细胞不影响抗体形成。此外，还报告了抗体和溶血卵磷脂类似物对接触敏感性发展的影响。
