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对三硝基苯基（TNP）决定簇的分裂无反应性。用苦味酰氯致敏抑制抗TNP抗体反应。

Split unresponsiveness to trinitrophenyl (TNP) determinant. Suppression of anti-TNP antibody responses by sensitization with picryl chloride.

作者信息

Rózycka D, Ptak W

出版信息

Immunology. 1978 Aug;35(2):229-35.

PMID:86500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457270/
Abstract

Contact sensitization by epicutaneous application of picryl chloride causes in mice a significant reduction of the antibody responses to immunogenic TNP-conjugates. This split unresponsiveness is along-lasting. It was found that hapten applied on the skin became attached to the serum proteins and the transfer of such a serum into normal recipients, while not influencing the ability of these animals to become contact-sensitized to PCl, rendered them unable to mount the anti-TNP antibody response. Possible mechanisms of split unresponsiveness to the TNP determinant induced by PCl treatment are suggested.

摘要

通过皮内涂抹苦味酸氯在小鼠中引起的接触致敏会导致对免疫原性三硝基苯（TNP）偶联物的抗体反应显著降低。这种分裂性无反应状态持续时间很长。研究发现，涂抹在皮肤上的半抗原会附着在血清蛋白上，将这种血清转移到正常受体中，虽然不会影响这些动物对苦味酸氯产生接触致敏的能力，但会使它们无法产生抗TNP抗体反应。文中提出了苦味酸氯处理诱导对TNP决定簇产生分裂性无反应状态的可能机制。

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Split unresponsiveness to trinitrophenyl (TNP) determinant. Suppression of anti-TNP antibody responses by sensitization with picryl chloride.对三硝基苯基（TNP）决定簇的分裂无反应性。用苦味酰氯致敏抑制抗TNP抗体反应。
Immunology. 1978 Aug;35(2):229-35.
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引用本文的文献

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本文引用的文献

1
Elicitation of allergic contact dermatitis in the guinea pig; the distribution of bound dinitrobenzene groups within the skin and quantitative determination of the extent of combination of 2,4-dinitro-chlorobenzene with epidermal protein in vivo.豚鼠过敏性接触性皮炎的诱发；皮肤内结合二硝基苯基团的分布以及体内2,4-二硝基氯苯与表皮蛋白结合程度的定量测定。
J Exp Med. 1958 Dec 1;108(6):773-96. doi: 10.1084/jem.108.6.773.
2
Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins.三硝基苯基-血蓝蛋白的免疫原性：一级和二级抗半抗原沉淀素的产生
J Immunol. 1966 Sep;97(3):421-30.
3
Studies on the sensitization of animals with simple chemical compounds. XI. The fate of labeled picryl chloride and dinitrochlorobenzene after sensitizing injections.用简单化合物使动物致敏的研究。十一、致敏注射后标记的氯化苦基和二硝基氯苯的命运。
J Exp Med. 1969 Jan 1;129(1):81-102. doi: 10.1084/jem.129.1.81.
4
Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
5
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
6
The distribution of 2,4-dinitrophenyl groups in guinea pig skin following surface application of 2,4-dinitrochlorobenzene: an immunofluorescent study.2,4-二硝基氯苯经皮应用后豚鼠皮肤中2,4-二硝基苯基的分布：一项免疫荧光研究。
J Invest Dermatol. 1971 Oct;57(4):269-77. doi: 10.1111/1523-1747.ep12261593.
7
Tolerance and contact sensitivity to DNFB in mice. I. In vivo detection by ear swelling and correlation with in vitro cell stimulation.小鼠对二硝基氟苯的耐受性和接触敏感性。I. 通过耳部肿胀进行体内检测及其与体外细胞刺激的相关性
J Immunol. 1974 Jan;112(1):115-23.
8
The tolerant cell: direct evidence for receptor blockade by tolerogen.耐受细胞：耐受原对受体阻断的直接证据。
J Immunol. 1974 May;112(5):1793-803.
9
Hapten competition and the nature of cell-cooperation in the antibody response.半抗原竞争与抗体应答中细胞协作的本质。
Proc R Soc Lond B Biol Sci. 1971 Jan 12;176(1045):393-418. doi: 10.1098/rspb.1971.0003.
10
Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer.小鼠的接触性和迟发型超敏反应。I. 主动致敏和被动转移。
Immunology. 1968 Sep;15(3):405-16.