Nakano K, Nakano Y
Immunology. 1978 Jun;34(6):981-7.
The effects of cyclophosphamide (CY) thymectomy and splenectomy on the antigenic competition in contact hypersensitivity between dinitrofluorobenzene (DNFB) and picryl chloride (PCI) was investigated. Contact sensitivity of PCI was suppressed by a prior painting of DNFB. When these two sensitizers were painted 7 days apart and CY was injected 3 days after the painting of DNFB, the antigenic competition did not occur. On the other hand, when CY was injected 3 days before painting of DNFB, the antigenic competition was partially abolished. The antigenic competition was seen in mice 2 weeks after adult thymectomy and in splenectomized mice. However, antigenic competition did not occur in mice 6 weeks after thymectomy. These results suggest that some thymus-derived cells may be involved in the antigenic competition in contact sensitivity.
研究了环磷酰胺（CY）、胸腺切除和脾切除对二硝基氟苯（DNFB）和苦味酰氯（PCI）之间接触性超敏反应中抗原竞争的影响。预先涂抹DNFB可抑制PCI的接触敏感性。当这两种致敏剂间隔7天涂抹且在涂抹DNFB 3天后注射CY时，未发生抗原竞争。另一方面，当在涂抹DNFB 3天前注射CY时，抗原竞争部分消除。在成年胸腺切除术后2周的小鼠和脾切除小鼠中可见抗原竞争。然而，胸腺切除术后6周的小鼠未发生抗原竞争。这些结果表明，一些胸腺来源的细胞可能参与接触敏感性中的抗原竞争。
