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L3T4 antigen expression by hemopoietic precursor cells.造血前体细胞的L3T4抗原表达。
J Exp Med. 1989 Apr 1;169(4):1473-8. doi: 10.1084/jem.169.4.1473.
2
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本文引用的文献

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A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.正常小鼠骨髓细胞辐射敏感性的直接测量。
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Light scattering properties of murine hemopoietic cells.小鼠造血细胞的光散射特性。
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Transient nature of early haematopoietic spleen colonies.早期造血脾集落的短暂性质。
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Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.用单克隆抗体GK1.5鉴定的小鼠T细胞表面分子L3T4的特性：L3T4与人Leu-3/T4分子的相似性
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The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.T细胞上主要组织相容性复合体限制的抗原受体。II. L3T4产物的作用。
J Exp Med. 1983 Oct 1;158(4):1077-91. doi: 10.1084/jem.158.4.1077.
6
Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines.有证据表明L3T4参与II类主要组织相容性复合体（MHC）抗原反应；单克隆抗体GK1.5（抗L3T4a）可阻断II类MHC抗原特异性增殖、淋巴因子释放以及克隆化小鼠辅助性T淋巴细胞系的结合。
J Immunol. 1983 Nov;131(5):2178-83.
7
Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.被单克隆抗体GK1.5识别的、命名为L3T4a的鼠类抗原决定簇的特性：功能性T细胞克隆对L3T4a的表达似乎主要与II类主要组织相容性复合体（MHC）抗原反应性相关。
Immunol Rev. 1983;74:29-56. doi: 10.1111/j.1600-065x.1983.tb01083.x.
8
Cell separation using positive immunoselective techniques.使用阳性免疫选择技术进行细胞分离。
J Immunol Methods. 1983 Feb 11;56(3):269-80. doi: 10.1016/s0022-1759(83)80016-7.
9
A stable propidium iodide staining procedure for flow cytometry.一种用于流式细胞术的稳定碘化丙啶染色程序。
J Histochem Cytochem. 1982 Sep;30(9):967-72. doi: 10.1177/30.9.6182188.
10
Thy-1 determinants are present on many murine hematopoietic cells other than T cells.Thy-1决定簇存在于许多除T细胞之外的小鼠造血细胞上。
Eur J Immunol. 1982 May;12(5):359-64. doi: 10.1002/eji.1830120502.

造血前体细胞的L3T4抗原表达。

L3T4 antigen expression by hemopoietic precursor cells.

作者信息

Frederickson G G, Basch R S

机构信息

Department of Pathology, New York University School of Medicine, New York 10016.

出版信息

J Exp Med. 1989 Apr 1;169(4):1473-8. doi: 10.1084/jem.169.4.1473.

DOI:10.1084/jem.169.4.1473
PMID:2784487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189248/
Abstract

L3T4 (CD4) is expressed on immature hematopoietic cells. Sorting bone marrow cells on the basis of their expression of this antigen produces populations of cells that are markedly enriched for multipotential stem cells (CFU-s) and for myeloid precursors (CFU-c). We believe that L3T4 is transiently expressed by most, if not all, hematopoietic precursors early in their maturation. We suggest that the expression of CD4 molecules on the surface of immature precursors is required for their interaction with Ia bearing cells within the hemopoietic inductive microenvironment(s) of the marrow and thymus.

摘要

L3T4（CD4）在未成熟造血细胞上表达。根据该抗原的表达对骨髓细胞进行分选，可产生明显富含多能干细胞（CFU-s）和髓系前体细胞（CFU-c）的细胞群体。我们认为，大多数（如果不是全部）造血前体细胞在其成熟早期会短暂表达L3T4。我们提出，未成熟前体细胞表面CD4分子的表达是其与骨髓和胸腺造血诱导微环境中携带Ia的细胞相互作用所必需的。