Turan Mahfuz, Ucler Rıfkı, Garca Mehmet Fatih, Kurdoglu Zehra, Cankaya Hakan, Ayral Abdurrahman, Bozan Nazım, Kıroglu Ahmet Faruk, Kurdoglu Mertihan
Department of Otorhinolaryngology, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
Department of Endocrinology and Metabolism, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
Med Sci Monit. 2016 Nov 15;22:4380-4385. doi: 10.12659/msm.898670.
BACKGROUND The purpose of our study was to investigate the association between polycystic ovary syndrome (PCOS) and hearing thresholds. MATERIAL AND METHODS Forty women diagnosed with PCOS (mean age, 24.33±6.38 years) and 40 healthy women controls (mean age, 26.38±6.75 years) were included in prospective study. Each case was tested with low (250, 500, 1000, and 2000 Hz), high (4000, 6000, and 8000 Hz) and extended high (EH) (9000-20000 Hz) frequency audiometry. The fasting plasma glucose, insulin, FSH, LH, total testosterone, and sex hormone-binding globulin were measured in all patients. RESULTS The mean hearing thresholds at EH frequencies were statistically significantly higher in the PCOS group than in the control group (p=0.001 right ear and p=0.015 left ear). There were significant positive correlations among free testosterone index (FTI) values and hirsutism scores with EH frequency hearing thresholds. CONCLUSIONS At pure-tone audiometry (PTA) EH frequencies, we detected significantly higher hearing thresholds in PCOS patients than in controls. We also determined that elevated FTI and hirsutism score were positively correlated with elevated hearing thresholds in EH frequencies. These findings support that hyperandrogenism can play a role in the elevation of hearing thresholds in PCOS.
背景 我们研究的目的是调查多囊卵巢综合征（PCOS）与听力阈值之间的关联。
材料与方法 40名被诊断为PCOS的女性（平均年龄24.33±6.38岁）和40名健康女性对照（平均年龄26.38±6.75岁）被纳入前瞻性研究。对每个病例进行低频（250、500、1000和2000赫兹）、高频（4000、6000和8000赫兹）和扩展高频（EH）（9000 - 20000赫兹）听力测定。对所有患者测量空腹血糖、胰岛素、促卵泡激素（FSH）、促黄体生成素（LH）、总睾酮和性激素结合球蛋白。
结果 PCOS组EH频率的平均听力阈值在统计学上显著高于对照组（右耳p = 0.001，左耳p = 0.015）。游离睾酮指数（FTI）值和多毛症评分与EH频率听力阈值之间存在显著正相关。
结论 在纯音听力测定（PTA）的EH频率下，我们检测到PCOS患者的听力阈值显著高于对照组。我们还确定，升高的FTI和多毛症评分与EH频率下升高的听力阈值呈正相关。这些发现支持高雄激素血症在PCOS听力阈值升高方面可能起作用。
