Hotta Jaakko, Saari Jukka, Koskinen Miika, Hlushchuk Yevhen, Forss Nina, Hari Riitta
Systems and Clinical Neuroscience, Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland; Aalto NeuroImaging, Aalto University School of Science, Espoo, Finland; Department of Neurology, Helsinki University Hospital, and Clinical Neurosciences, Neurology, University of Helsinki, Finland.
Systems and Clinical Neuroscience, Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
J Pain. 2017 Mar;18(3):255-265. doi: 10.1016/j.jpain.2016.10.017. Epub 2016 Nov 12.
Patients with complex regional pain syndrome (CRPS) display various abnormalities in central motor function, and their pain is intensified when they perform or just observe motor actions. In this study, we examined the abnormalities of brain responses to action observation in CRPS. We analyzed 3-T functional magnetic resonance images from 13 upper limb CRPS patients (all female, ages 31-58 years) and 13 healthy, age- and sex-matched control subjects. The functional magnetic resonance imaging data were acquired while the subjects viewed brief videos of hand actions shown in the first-person perspective. A pattern-classification analysis was applied to characterize brain areas where the activation pattern differed between CRPS patients and healthy subjects. Brain areas with statistically significant group differences (q < .05, false discovery rate-corrected) included the hand representation area in the sensorimotor cortex, inferior frontal gyrus, secondary somatosensory cortex, inferior parietal lobule, orbitofrontal cortex, and thalamus. Our findings indicate that CRPS impairs action observation by affecting brain areas related to pain processing and motor control.
This article shows that in CRPS, the observation of others' motor actions induces abnormal neural activity in brain areas essential for sensorimotor functions and pain. These results build the cerebral basis for action-observation impairments in CRPS.
复杂性区域疼痛综合征（CRPS）患者在中枢运动功能方面表现出各种异常，并且当他们执行或仅仅观察运动动作时，疼痛会加剧。在本研究中，我们检查了CRPS患者对动作观察的脑反应异常。我们分析了13例上肢CRPS患者（均为女性，年龄31 - 58岁）和13名年龄、性别匹配的健康对照者的3-T功能磁共振图像。在受试者观看以第一人称视角展示的手部动作简短视频时采集功能磁共振成像数据。应用模式分类分析来表征CRPS患者和健康受试者之间激活模式不同的脑区。具有统计学显著组间差异（q <.05，错误发现率校正）的脑区包括感觉运动皮层中的手部代表区、额下回、次级体感皮层、顶下小叶、眶额皮层和丘脑。我们的研究结果表明，CRPS通过影响与疼痛处理和运动控制相关的脑区来损害动作观察。
本文表明，在CRPS中，观察他人的运动动作会在感觉运动功能和疼痛所必需的脑区诱发异常神经活动。这些结果为CRPS中动作观察障碍建立了脑基础。
