Torbohm I, Berger B, Schönermark M, von Kempis J, Rother K, Hänsch G M
Institut für Immunologie, Universität Heidelberg, FRG.
Clin Exp Immunol. 1989 Mar;75(3):427-31.
Human glomerular epithelial cells produce matrix material e.g. collagen type IV. In vitro, the synthesis of collagen can be monitored by the incorporation of 3H-proline, a precursor molecule of the collagens. We report on the enhancement of collagen synthesis by glomerular epithelial cells with highly purified or recombinant I1-1. Since I1-1 is released from monocytes or glomerular mesangial cells by inflammatory mediators, our results point to a participation of I1-1 in the development of sclerosis, which is seen in many forms of chronic inflammatory diseases.
人肾小球上皮细胞产生基质物质，例如IV型胶原。在体外，胶原的合成可通过掺入3H-脯氨酸（胶原的前体分子）来监测。我们报道了用高度纯化的或重组的白细胞介素-1增强肾小球上皮细胞的胶原合成。由于白细胞介素-1可由炎症介质从单核细胞或肾小球系膜细胞中释放出来，我们的结果表明白细胞介素-1参与了硬化的发展过程，这在多种慢性炎症性疾病中都可见到。
