de Alarcon P A, Miller M L, Stuart M J
Am J Dis Child. 1978 Aug;132(8):763-4.
A 3-year-old girl had pancytopenia and bone marrow erythroid hypoplasia. The pancytopenia resolved without therapy, but the erythroid hypoplasia persisted for four months in spite of a five-week course of corticosteroid therapy. She responded briefly when androgens were added to the corticosteroid regimen, but within three weeks of stopping therapy she developed acute lymphocytic leukemia. The differential diagnosis of RBC aplasia in childhood is discussed. To our knowledge, this is the first case reported with erythroid hypoplasia as a prodrome of acute lymphocytic leukemia of childhood.
一名3岁女童出现全血细胞减少和骨髓红系造血低下。全血细胞减少未经治疗自行缓解，但尽管接受了为期五周的皮质类固醇治疗，红系造血低下仍持续了四个月。在皮质类固醇治疗方案中加入雄激素后，她曾有短暂反应，但在停药三周内，她发展为急性淋巴细胞白血病。本文讨论了儿童红细胞再生障碍的鉴别诊断。据我们所知，这是第一例报道以红系造血低下作为儿童急性淋巴细胞白血病前驱症状的病例。
