Mooney M P, Siegel M I, Kimes K R, Todhunter J
Department of Anthropology, School of Dental Medicine, University of Pittsburgh, PA.
Cleft Palate J. 1989 Apr;26(2):93-9; discussion 99.
Predictions about the temporal sequencing (i.e., primacy) and causal relationships between various midfacial growth components, as suggested by two midfacial growth models (functional matrix and septal traction), were examined in the present study. The relationships between quantitative changes in the nasal septum, nasal airway, nasolabial musculature, and premaxilla of 15 normal human fetal specimens, ranging in age from 12 to 20 weeks postmenstrual age, were assessed using the multivariate technique of path analysis. Path analysis results revealed that the causal sequence of variables proposed by the septal-traction model explained more of the variance in premaxillary size (87 percent goodness-of-fit) than did the sequence of variables proposed by the functional matrix model (65 percent goodness-of-fit). These results suggest that the septal-traction model may be a more parsimonious and primary explanation of early human fetal midfacial growth than the functional matrix model. Path analysis results also reiterate the observed complex developmental relationships within the fetal labioseptopremaxillary region, knowledge of which may be important in the surgical management of infants with complete cleft.
本研究检验了两种面中部生长模型（功能基质模型和鼻中隔牵引模型）所提出的关于面中部各生长成分之间的时间顺序（即先后顺序）和因果关系的预测。采用路径分析的多变量技术，评估了15例月经龄为12至20周的正常人类胎儿标本的鼻中隔、鼻气道、鼻唇肌组织和上颌前部的定量变化之间的关系。路径分析结果显示，鼻中隔牵引模型提出的变量因果序列比功能基质模型提出的变量序列能解释更多上颌前部大小的方差（拟合优度为87%）（拟合优度为65%）。这些结果表明，与功能基质模型相比，鼻中隔牵引模型可能是对人类胎儿早期面中部生长更简洁、更基本的解释。路径分析结果还重申了在胎儿唇-鼻中隔-上颌前部区域观察到的复杂发育关系，了解这些关系可能对完全性腭裂婴儿的手术治疗很重要。
