Zabriskie J B, Lavenchy D, Williams R C, Fu S M, Yeadon C A, Fotino M, Braun D G
Arthritis Rheum. 1985 Sep;28(9):1047-51. doi: 10.1002/art.1780280912.
Mice immunized with B lymphocytes obtained from patients who had had well-documented rheumatic fever in the past yielded 2 monoclonal antibodies, termed 83S19.23 and 256S10, which identified certain alloantigens present on the B cells of these patients. The frequency of the B cell marker detected by clone 83S19.23 in rheumatic fever patients was found to be 59%, 77%, and 74% in India, New Mexico, and New York, respectively. Monoclonal antibody 256S10 identified 75% of those rheumatic fever patients who were nonreactive to clone 83S19.23. Thus, the 2 antibodies identify approximately 92% of all rheumatic fever patients and suggest the presence of a diallelic genetic marker for susceptibility to rheumatic fever.
用曾患过有充分记录的风湿热患者的B淋巴细胞免疫的小鼠产生了2种单克隆抗体，分别称为83S19.23和256S10，它们识别这些患者B细胞上存在的某些同种异体抗原。发现在印度、新墨西哥和纽约，克隆83S19.23检测到的风湿热患者中B细胞标志物的频率分别为59%、77%和74%。单克隆抗体256S10识别出75%对克隆83S19.23无反应的风湿热患者。因此，这两种抗体识别了约92%的所有风湿热患者，并提示存在风湿热易感性的双等位基因遗传标志物。
