Vysloužilová Lucie, Buzgo Matej, Pokorný Pavel, Chvojka Jiří, Míčková Andrea, Rampichová Michala, Kula Jiří, Pejchar Karel, Bílek Martin, Lukáš David, Amler Evžen
Department of Nonwovens, Technical University of Liberec Studentska 2, 461 17 Liberec, Czechia.
Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, V Úvalu 84, 150 06, Prague 5, Czechia; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czechia; University Centre for Energy Efiicient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Bustehrad, Czechia.
Int J Pharm. 2017 Jan 10;516(1-2):293-300. doi: 10.1016/j.ijpharm.2016.11.034. Epub 2016 Nov 13.
Herein, we describe a simple spinneret setup for needleless coaxial electrospinning that exceeds the limited production capacity of current approaches. The proposed weir spinneret enables coaxial electrospinning from free liquid surface. This approach leads to the formation of coaxial nanofibers with higher and uniform shell/core ratio, which results in the possibility of better tuning of the degradation rate. The throughput and quality increase favor the broader application of coaxial nanofibers from weir spinnerets as systems for controlled drug delivery in regenerative medicine and tissue engineering.
在此，我们描述了一种用于无针同轴电纺丝的简单喷丝头装置，其超越了当前方法有限的生产能力。所提出的堰式喷丝头能够从自由液体表面进行同轴电纺丝。这种方法导致形成具有更高且均匀的壳/核比的同轴纳米纤维，这使得更好地调节降解速率成为可能。产量和质量的提高有利于将堰式喷丝头的同轴纳米纤维作为再生医学和组织工程中可控药物递送系统进行更广泛的应用。
