Su Yan, Su Qianqian, Liu Wei, Jin Guori, Mo Xiumei, Ramakrishn Seeram
a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, P. R. China; Biomaterials and Tissue Engineering Laboratory, College of Chemistry and Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P. R. China; Faculty of Engineering, Department of Mechanical Engineering, National University of Singapore, 117543, Singapore.
J Biomater Sci Polym Ed. 2012;23(7):861-71. doi: 10.1163/092050611X564137.
The purpose of this work was to develop a type of tissue-engineering scaffold or drug-delivery carrier with the capability of encapsulation and controlled release of dual drugs. In this study, Rhodamine B and bovine serum albumin (BSA) were successfully incorporated into nanofibers by means of blending or coaxial electrospinning. The morphology of composite nanofibers was studied by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The composite nanofibrous mats made from coaxial electrospinning were characterized by X-ray diffraction. In vitro dual-drug release behaviors from composite nanofibrous mats were investigated. From the drug-release profiles, it shows that the location where the drug or protein is put into (into the core or shell of the nanofibers) can affect the drug-release profile in the coaxially electrospun fibers. The results imply that the drug- and/or protein-release profile in composite fibrous mats made from electrospinning can be controlled by altering the coaxial electrospinning process and has significant implications for a wide range of applications such as tissue regeneration, combined therapies or even cancer treatments.
这项工作的目的是开发一种具有封装和控制释放两种药物能力的组织工程支架或药物递送载体。在本研究中，通过共混或同轴静电纺丝成功地将罗丹明B和牛血清白蛋白（BSA）掺入纳米纤维中。通过扫描电子显微镜（SEM）和透射电子显微镜（TEM）研究了复合纳米纤维的形态。用X射线衍射对同轴静电纺丝制备的复合纳米纤维毡进行了表征。研究了复合纳米纤维毡的体外双药释放行为。从药物释放曲线可以看出，药物或蛋白质放入的位置（纳米纤维的芯部或壳部）会影响同轴静电纺丝纤维中的药物释放曲线。结果表明，通过改变同轴静电纺丝工艺可以控制静电纺丝制备的复合纤维毡中药物和/或蛋白质的释放曲线，这对组织再生、联合治疗甚至癌症治疗等广泛应用具有重要意义。
