Tidwell R R, Kilgore S G, Ohemeng K A, Geratz J D, Hall J E
Department of Pathology, University of North Carolina, Chapel Hill 27599.
J Protozool. 1989 Jan-Feb;36(1):74S-76S. doi: 10.1111/j.1550-7408.1989.tb02711.x.
Seven analogs of pentamidine were tested for their activity against an immunosuppressed rat model of Pneumocystis carinii pneumonia. Structural alterations of the pentamidine molecule included variations of the alkyl chain linking the two p-amidino phenoxy moieties and relocation of the amidine groups from the para to the meta position on the phenoxy rings. All analogs of pentamidine were active against P. carinii pneumonia when compared to a saline-treated control group. One derivative, 1, 4-di(4'-amidinophenoxy)butane, proved to be statistically more active than the parent drug.
对喷他脒的七种类似物进行了测试，以检测它们对卡氏肺孢子虫肺炎免疫抑制大鼠模型的活性。喷他脒分子的结构改变包括连接两个对脒基苯氧基部分的烷基链的变化以及脒基从苯氧基环上的对位重新定位到间位。与生理盐水处理的对照组相比，所有喷他脒类似物对卡氏肺孢子虫肺炎均有活性。一种衍生物1,4-二（4'-脒基苯氧基）丁烷在统计学上被证明比母体药物更具活性。
